Compounds > N-[7-(2-furanyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]acetamide
Page last updated: 2024-11-09

N-[7-(2-furanyl)-5-oxo-7,8-dihydro-6H-quinazolin-2-yl]acetamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID2886431
CHEMBL ID1304927
CHEBI ID117253
SCHEMBL ID17792864

Synonyms (26)

Synonym
smr000121354
MLS000528879 ,
n-(7-furan-2-yl-5-oxo-5,6,7,8-tetrahydro-quinazolin-2-yl)-acetamide
CHEMDIV2_000429
OPREA1_116806
OPREA1_641420
n-[7-(furan-2-yl)-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl]acetamide
STK138760
CHEBI:117253
HMS1370D11
AKOS000623951
n-[7-(furan-2-yl)-5-oxo-7,8-dihydro-6h-quinazolin-2-yl]acetamide
CHEMBL1304927
CCG-17641
HMS2334I13
AKOS016308479
n-[7-(2-furyl)-5-keto-7,8-dihydro-6h-quinazolin-2-yl]acetamide
n-[7-(furan-2-yl)-5-oxidanylidene-7,8-dihydro-6h-quinazolin-2-yl]ethanamide
n-[7-(2-furanyl)-5-oxo-7,8-dihydro-6h-quinazolin-2-yl]acetamide
cid_2886431
bdbm68702
Q27203889
SCHEMBL17792864
SR-01000451150-1
sr-01000451150
354538-14-0
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
quinazolinesAny organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency5.62340.004023.8416100.0000AID485290
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency56.23410.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Serine hydroxymethyltransferase, mitochondrialHomo sapiens (human)IC50 (µMol)4.57000.43653.58839.7700AID1619186
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC50 (µMol)300.00000.212522.156283.9400AID434954
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (15)

Processvia Protein(s)Taxonomy
regulation of oxidative phosphorylationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
glycine metabolic processSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
L-serine metabolic processSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
L-serine biosynthetic processSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
one-carbon metabolic processSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
positive regulation of cell population proliferationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
response to type I interferonSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
tetrahydrofolate interconversionSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
tetrahydrofolate metabolic processSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
protein tetramerizationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
protein homotetramerizationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
regulation of mitochondrial translationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
protein K63-linked deubiquitinationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
regulation of aerobic respirationSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
glycine biosynthetic process from serineSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
chromatin bindingSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
glycine hydroxymethyltransferase activitySerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
protein bindingSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
L-allo-threonine aldolase activitySerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
amino acid bindingSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
pyridoxal phosphate bindingSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
identical protein bindingSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (9)

Processvia Protein(s)Taxonomy
nucleusSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
cytoplasmSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
mitochondrionSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
mitochondrial inner membraneSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
mitochondrial matrixSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
microtubule cytoskeletonSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
mitochondrial nucleoidSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
extracellular exosomeSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
BRISC complexSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
mitochondrionSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
cytoplasmSerine hydroxymethyltransferase, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.22 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510
Plasmodium falciparum Malaria
[description not available]		02.110
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.		02.110